FDA-approved (Semaglutide, Tirzepatide) vs telehealth-prescribed compounded vs research-grey. The peptide category audited without supplement-industry spin. The honest framework for what works, what is unproven, what we will not write a buying guide for.
GLP-1s (Semaglutide, Tirzepatide) have the strongest weight-loss data ever produced by any pharmacological class — 14.9% to 20.9% loss in placebo-controlled trials. Below that tier is a long tail of "research peptides" with promising animal data and minimal human evidence. We do not write buying guides for the third tier.
Read the cover story →The 3-4 follow-up articles that go deepest on your situation.
The cardiovascular question got answered. The conversation just changed.
What nobody tells you about muscle loss, gallstones, off-ramp, and the chronic-use framing.
Sleep, protein floor, resistance, alcohol. Without these, GLP-1 weight loss becomes mostly muscle.
Each product is something we have read the trials on or personally used. Evidence note included. Some links are affiliate — disclosed on every CTA. No supplement-brand sponsorships, ever.
Telehealth-prescribed FDA-approved GLP-1 medications. Clinical oversight, lab monitoring, dose titration. The legit tier-1 path for weight loss in the 12-25% range.
GLP-1 weight loss is 60% fat / 40% lean mass without protein floor + resistance training. The single non-negotiable companion to any GLP-1 protocol. Momentous is NSF Certified for Sport.
Continuous glucose monitoring. The most useful single dataset for understanding your metabolic flexibility — meaningful for men optimizing body comp, recovery, and cognition.
Sleep is the body comp lever GLP-1 doesn't fix. The protocol that compounds with the medication.
See the course →The Sunday letters most relevant to your stated concern. Free, sent weekly, reply to anything.
One long-form research-led piece every Sunday. Free forever. Reply to anything — Alexander reads every response.