Men's health after 40 — everything After Forty Feel has written.
→ Start with the Hormone Age Calculator (90 sec, free) — gender-routed result
The science of midlife male health, written without bro-internet hype, without supplement sponsorships, and with citations you can verify. TRT, peptides, bloodwork, mental health, libido. Start wherever the question is loudest.
If you've been wondering whether TRT is real medicine or vanity drugs
TRT after 40 — the decision framework after the 2024 reanalysis
The 2024 TRAVERSE trial in NEJM finally settled the cardiovascular question. Most prescribers haven't caught up. Who actually benefits, the labs that matter, and the difference between TRT and the peptide stack you've been seeing on YouTube.
The single most important midlife-men piece we publish
Men's mental health at 45 — what the suicide-rate peak is telling us
Men 45-54 die by suicide at roughly 4x the rate of women in the same band — the highest of any demographic in the US. The presentation looks nothing like what the depression screens test for. The biology, the data, what actually works, ranked by evidence.
The bloodwork the annual physical doesn't run
The 8 labs every man over 45 should run every year
HbA1c (not just glucose), fasting insulin, ApoB (not just LDL), free + total T + SHBG, hs-CRP, vitamin D, ferritin, PSA. With optimal ranges — not the population averages on your lab report — and what to do with the results.
Peptides — what's research, what's marketing
Peptides for men 40+ — what's real, what's hype
BPC-157, ipamorelin/CJC-1295, tesamorelin sorted by evidence tier. The Russian neuropeptides to skip. The 503A compounding restrictions that complicate sourcing. The honest assessment: useful for men with the basics dialed, useless if the basics aren't.
The conversation no one starts but everyone needs
Libido and ED at 45+ — the cardiovascular canary most men don't know about
The Princeton III consensus codified what cardiologists know: new-onset ED in a midlife man predicts cardiovascular events 3-5 years out. The mechanism, the real workup (it's not "here's tadalafil"), and what actually moves the needle.
The pathway approach
TRT for men 40-60 — clinician-ready decision tree
From "something shifted, I don't know what" to "I have an evidence-backed plan I can discuss with my doctor." Bloodwork checklist, decision branches, the questions to ask, the red flags that mean don't.
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